Bottom of the seventh inning, two outs bases loaded, down two runs, and Terry Francona ends up with Alex Cora facing a LHP (Jamie Walker)??? Of all the possible hitter-pitcher matchups involving Red Sox hitter, Cora v. a LHP is the least desirable (maybe Mirabelli v. a RHP).
It's also worth noting that Cora was pinch hitting, and research done in The Book suggests a 21 point drop in wOBA for a pinch hitter. (Click my name for a link to the story). Dumb, dumb, dumb stuff.

Lets not forget two unreal defensive plays from Tejada to rob the sox of hits.

yeah, i just caught the highlights, but it looked like the sox were hitting the ball hard right at people all night. is that right?

Sorta. Tejada made a leaping snare of a well-struck JD Drew line-drive and almost doubled off Lowell at second with the bases loaded and one out in the game-deciding 7th inning. Had it gone through, Boston would have tied the game, at least. In the fifth, Varitek crushed one to deep right with Lowell on first and one out. Would have gone for extra-bases, and Lowell would have either scored or ended up on 3rd with 1 out. But Markakis made a great leaping grab just before the warning track, and Lowell barely made it back to first base.

Those were really the two big, game-changing plays. Though in the first, Youkilis hit a 2-out line-drive single to LF with Papi on second...but he hit it right at Gibbons and too hard for the runner to score. To end the inning, Lowell was caught looking at a 3rd strike that, according to the radio guys, was way low and well inside; "an awful pitch, nowhere close."

Just one of those days, like you say.