Craig Edwards at FanGraphs makes a point about the potential use of a universal DH during a shortened 2020 season:

While sticking to the interleague rule where the home ballpark dictates whether the designated hitter is in use might be feasible, given that the standard divisions don’t exist, going to a universal designated hitter might be an easier solution. It also might be slightly safer, helping to prevent pitcher injuries in a shortened season. But should a universal DH be adopted, NL teams will be at a significant disadvantage at the plate this season.

FanGraphs.com

He goes on to show who is mostly likely to serve as DH on each NL team, and how that might help or hurt the team’s win column. For example, moving a defensively challenged hitter like Daniel Murphy to designated hitter helps the Rockies, but the Mets moving Dominic Smith to the position hurts the team.

I do not quite share the pessimism, as teams will have time to adjust. I suspect there are a few young slugging first basemen in the minors with poor fielding ability. They can’t make it to the majors, since most young players are expected to be fielders of some sort. No one drafts a designated hitter. These players need to prove their defense isn’t up to the major league level first. So someone like Hunter Pence, so is fine to have on the bench as a pinch hitter, fall further down the depth chart. He will be replaced by someone who can be productive in four plate appearances a day.